BYK204165

BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1[1].

Product Specifications

CAS Number

[1104546-89-5]

UNSPSC

12352005

Hazard Statement

H317

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/byk204165.html

Purity

98.66

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1NC(/C(C2=C1C=CC=C2)=C\C3=CC=CN3C)=O

Molecular Formula

C15H12N2O2

Molecular Weight

252.27

Precautions

H317

References & Citations

[1]Eltze T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly (ADP-ribose) polymerase (PARP) : a comparison with standard PARP inhibitors. Mol Pharmacol. 2008 Dec;74 (6) :1587-98.