BYK204165
BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1[1].
Product Specifications
CAS Number
[1104546-89-5]
UNSPSC
12352005
Hazard Statement
H317
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/byk204165.html
Purity
98.66
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NC(/C(C2=C1C=CC=C2)=C\C3=CC=CN3C)=O
Molecular Formula
C15H12N2O2
Molecular Weight
252.27
Precautions
H317
References & Citations
[1]Eltze T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly (ADP-ribose) polymerase (PARP) : a comparison with standard PARP inhibitors. Mol Pharmacol. 2008 Dec;74 (6) :1587-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2
Available Sizes
Curated Selection
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