AEEA-AEEA
AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Product Specifications
CAS Number
[1143516-05-5]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aeea-aeea.html
Purity
99.12
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)COCCOCCNC(COCCOCCN)=O
Molecular Formula
C12H24N2O7
Molecular Weight
308.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
Curated Selection
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