Flecainide

Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2) . Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) [1][2].

Product Specifications

CAS Number

[54143-55-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/flecainide.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(OCC(F)(F)F)=CC=C1OCC(F)(F)F)NCC2NCCCC2

Molecular Formula

C17H20F6N2O3

Molecular Weight

414.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Watanabe H, et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med. 2009 Apr;15 (4) :380-3. |[2]Kuroda Y, et al. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochem Biophys Rep. 2017 Jan 11;9:245-256.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

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