SBP-0636457
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2].
Product Specifications
CAS Number
1422180-49-1
Product Name Alternative
SBI-0636457; SB1-0636457
UNSPSC
12352005
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sbp-0636457.html
Purity
98.42
Solubility
DMSO : 45.71 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@@H]1C(C)(C)C[C@](N21)([H])OCC[C@H](NC([C@@H](NC)C)=O)C2=O)N[C@@H]3CCCC4=C3C=CC=C4
Molecular Formula
C25H36N4O4
Molecular Weight
456.58
References & Citations
[1]Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13 (1) : 5-15.|[2]Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
XIAP
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC043308-100 1x 100 µL
Napsin A (Lung Adenocarcinoma Marker) (NAPSA/3308), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
QACE1-100 100 Tests
QuantiFluo™ Angiotensin-Converting Enzyme 1 Assay Kit
Sign In for Pricing
View Details 
