Ivacaftor-d9
Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].
Product Specifications
CAS Number
[1413431-07-8]
Product Name Alternative
VX-770-d9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CFTR
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.44
Solubility
DMSO : 50mg/mL (ultrasonic)
Smiles
CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C
Molecular Formula
C24H19D9N2O3
Molecular Weight
401.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362 (2) :359-367.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Launched
Available Sizes
Curated Selection
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