(1S,2S,3R) -DT-061
(1S,2S,3R) -DT-061 is an enantiomer of DT-061 (HY-112929) . DT-061 is an orally active activator of protein phosphatase 2A (PP2A) . (1S,2S,3R) -DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis[1].
Product Specifications
CAS Number
[1809427-20-0]
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1s-2s-3r-dt-061.html
Purity
99.77
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@@H]2[C@@H](O)[C@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O
Molecular Formula
C25H23F3N2O5S
Molecular Weight
520.52
References & Citations
[1]Kauko O, et al. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med. 2018 Jul 18;10 (450) . pii: eaaq1093.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
M2350-02B-ML550 100 µL
MAP2, NT (Microtubule Associated Protein 2, MAP-2) (MaxLight 550) discontinued
Ask
View Details 
![BCL10 Mouse Monoclonal Antibody [Clone ID: 24GB2925]](https://cdn.genprice.uk/products/937/6868c301994c49e6dc3ed249/imageurl/ta425347.webp)