ICCB-19 (hydrochloride)
ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins[1].
Product Specifications
CAS Number
1803605-68-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/iccb-19-hydrochloride.html
Purity
99.25
Solubility
DMSO : 83.33 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C(NC1CCCCCC1)CSC2=NCCN2.[H]Cl
Molecular Formula
C12H22ClN3OS
Molecular Weight
291.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Daichao Xu, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587 (7832) :133-138.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Available Sizes
Frequently Asked Questions
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