ICCB-19 (hydrochloride)
ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins[1].
Product Specifications
CAS Number
[1803605-68-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/iccb-19-hydrochloride.html
Purity
99.25
Solubility
DMSO : 83.33 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C(NC1CCCCCC1)CSC2=NCCN2.[H]Cl
Molecular Formula
C12H22ClN3OS
Molecular Weight
291.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Daichao Xu, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587 (7832) :133-138.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
