Rimacalib
Rimacalib (SMP 114) is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ[1].
Product Specifications
CAS Number
[215174-50-8]
Product Name Alternative
SMP 114
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; CaMK
Type
Reference compound
Related Pathways
Autophagy; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Rimacalib.html
Purity
99.14
Solubility
DMSO : 125 mg/mL (ultrasonic) |Ethanol : 16.67 mg/mL (ultrasonic)
Smiles
N=C(N1CCOCC1)NC2=CC([C@H](C3=CC=C(C4=CC=CC=C4)C(F)=C3)C)=NO2
Molecular Formula
C22H23FN4O2
Molecular Weight
394.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Neef S, et al. Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability. Basic Res Cardiol. 2017 Jul;112 (4) :45.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CaMK II
Available Sizes
Curated Selection
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