Desvenlafaxine (succinate hydrate)

Desvenlafaxine succinate hydrate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate hydrate shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

Product Specifications

CAS Number

[386750-22-7]

Product Name Alternative

O-Desmethylvenlafaxine (succinate hydrate)

UNSPSC

12352005

Hazard Statement

H302

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Desvenlafaxine-succinate-hydrate.html

Purity

99.82

Solubility

DMSO : ≥ 33 mg/mL

Smiles

OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1.O=C(O)CCC(O)=O.O

Molecular Formula

C20H33NO7

Molecular Weight

399.48

Precautions

H302

References & Citations

[1]Darlene C Deecher, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318 (2) :657-65.|[2]Michael A Sopko Jr, et al. Desvenlafaxine: another "me too" drug? Ann Pharmacother. 2008 Oct;42 (10) :1439-46.