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Atosiban (acetate)

Atosiban acetate (RW22164 acetate; RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research[1].

Product Specifications

CAS Number

914453-95-5

Product Name Alternative

RW22164 (acetate) ; RWJ22164 (acetate)

UNSPSC

12352209

Hazard Statement

H301, H311, H331

Target

Oxytocin Receptor; Vasopressin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/atosiban-acetate.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H](CSSCCC(N[C@@H](C1=O)CC2=CC=C(OCC)C=C2)=O)NC([C@@H](NC(C(NC([C@](N1)([H])[C@@H](C)CC)=O)[C@H](O)C)=O)CC(N)=O)=O)N(CCC3)[C@@H]3C(N[C@@H](CCCN)C(NCC(N)=O)=O)=O.OC(C)=O

Molecular Formula

C45H71N11O14S2

Molecular Weight

1054.24

Precautions

H301, H311, H331

References & Citations

[1]Sanu O, et al. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9.|[2]Philip J Ryan, et al. Oxytocin-receptor-expressing Neurons in the Parabrachial Nucleus Regulate Fluid Intake. Nat Neurosci. 2017 Dec;20 (12) :1722-1733.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

Launched

Citation 01

J Pharm Biomed Anal. 2022 Mar 20:211:114518.|Transl Psychiatry. 2024 May 25;14 (1) :208.|Curr Biol. 2025 Sep 26:S0960-9822 (25) 01182-0.|Front Neurosci. 2021 Sep 10:15:723064.|J Pharm Biomed Anal. 2023 Feb 5:224:115156.|Neurosci Bull. 2025 Aug 6.

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