Taranabant

Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro.

Product Specifications

CAS Number

[701977-09-5]

Product Name Alternative

MK-0364

UNSPSC

12352005

Hazard Statement

H372, H400

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Taranabant.html

Purity

99.14

Solubility

DMSO : ≥ 42 mg/mL

Smiles

ClC1=CC=C(C[C@@H](C2=CC=CC(C#N)=C2)[C@@H](NC(C(C)(OC3=CC=C(C=N3)C(F)(F)F)C)=O)C)C=C1

Molecular Formula

C27H25ClF3N3O2

Molecular Weight

515.95

Precautions

H372, H400

References & Citations

[1]Fong TM, et al. Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[ (1S,2S) -3- (4-Chlorophenyl) -2- (3-cyanophenyl) -1-methylpropyl]-2 -methyl-2-{[5- (trifluoromethyl) pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents. J Pharmacol Exp T|[2]Lin LS, et al. Discovery of N-[ (1S,2S) -3- (4-Chlorophenyl) -2- (3-cyanophenyl) -1-methylpropyl]-2-methyl-2- {[5- (trifluoromethyl) pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J M