Taranabant
Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro.
Product Specifications
CAS Number
701977-09-5
Product Name Alternative
MK-0364
UNSPSC
12352005
Hazard Statement
H372, H400
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Taranabant.html
Purity
99.14
Solubility
DMSO : ≥ 42 mg/mL
Smiles
ClC1=CC=C(C[C@@H](C2=CC=CC(C#N)=C2)[C@@H](NC(C(C)(OC3=CC=C(C=N3)C(F)(F)F)C)=O)C)C=C1
Molecular Formula
C27H25ClF3N3O2
Molecular Weight
515.95
Precautions
H372, H400
References & Citations
[1]Fong TM, et al. Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[ (1S,2S) -3- (4-Chlorophenyl) -2- (3-cyanophenyl) -1-methylpropyl]-2
 -methyl-2-{[5- (trifluoromethyl) pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents. J Pharmacol Exp T|[2]Lin LS, et al. Discovery of N-[ (1S,2S) -3- (4-Chlorophenyl) -2- (3-cyanophenyl) -1-methylpropyl]-2-methyl-2- {[5- (trifluoromethyl) pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J M
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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