PF-04620110

PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC50 of 19 nM[1].

Product Specifications

CAS Number

[1109276-89-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/PF-04620110.html

Purity

99.60

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C[C@@H]1CC[C@H](CC1)C2=CC=C(C=C2)N3CCOC4=NC=NC(N)=C4C3=O)O

Molecular Formula

C21H24N4O4

Molecular Weight

396.44

Precautions

H302

References & Citations

[1]Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21 (20) :6122-5.|[2]Dow RL, et al. Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1. ACS Med Chem Lett. 2011 Mar 18;2 (5) :407-12.