MG 149
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM) ; little potent for PCAF and p300 (IC50 >200 uM) . MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease[1][2][3].
Product Specifications
CAS Number
1243583-85-8
Product Name Alternative
Tip60 HAT inhibitor
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain; Histone Acetyltransferase; PINK1/Parkin
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mg-149.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2
Molecular Formula
C22H28O3
Molecular Weight
340.46
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; PINK1; TIP60
Available Sizes
Frequently Asked Questions
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