MG 149

MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM) ; little potent for PCAF and p300 (IC50 >200 uM) . MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease[1][2][3].

Product Specifications

CAS Number

[1243583-85-8]

Product Name Alternative

Tip60 HAT inhibitor

UNSPSC

12352005

Target

Apoptosis; Epigenetic Reader Domain; Histone Acetyltransferase; PINK1/Parkin

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Epigenetics; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/mg-149.html

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2

Molecular Formula

C22H28O3

Molecular Weight

340.46

References & Citations

[1]Ghizzoni M, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47 (1) :337-44.|[2]de Talhouët C, et al. KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy. Sci Rep. 2024 May 22;14 (1) :11721. |[3]Wang Y, et al. TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release. Clin Exp Hypertens. 2023 Dec 31;45 (1) :2259130.