Rabbit anti-SIGLEC-15 Monoclonal Antibody

<strong>Rabbit anti-SIGLEC-15 Monoclonal Antibody</strong>_x000D_ <strong>Catalog number:</strong> B2015583_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 20 µL (2 blots)_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8¬∞C_x000D_ <strong>Keywords:</strong> CD33 antigen-like 3;CD33 molecule-like 3;CD33L3;HsT1361;sialic acid-binding Ig-like lectin 15_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Tsukazaki H, Kikuta J, Ao T, Morimoto A, Fukuda C, Tsuda E, Minoshima M, Kikuchi K, Kaito T, Ishii M. Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation Bone. 2021 Nov;152:116095._x000D_ 2: Udagawa N, Koide M, Nakamura M, Nakamichi Y, Yamashita T, Uehara S, Kobayashi Y, Furuya Y, Yasuda H, Fukuda C, Tsuda E. Osteoclast differentiation by RANKL and OPG signaling pathways J Bone Miner Metab. 2021 Jan;39(1):19-26._x000D_ 3: Peng Y, Langermann S, Kothari P, Liu L, Zhao W, Hu Y, Chen Z, Moraes de Lima Perini M, Li J, Cao J, Guo XE, Chen L, Bauman WA, Qin W. Anti-Siglec-15 Antibody Prevents Marked Bone Loss after Acute Spinal Cord Injury-Induced Immobilization in Rats JBMR Plus. 2023 Sep 27;7(12):e10825._x000D_ 4: Tsuda E, Fukuda C, Okada A, Karibe T, Hiruma Y, Takagi N, Isumi Y, Yamamoto T, Hasegawa T, Uehara S, Koide M, Udagawa N, Amizuka N, Kumakura S. Characterization, pharmacokinetics, and pharmacodynamics of anti-Siglec-15 antibody and its potency for treating osteoporosis and as follow-up treatment after parathyroid hormone use Bone. 2022 Feb;155:116241._x000D_ 5: Wu J, Peng J, Zhou Y, Zhang R, Wang Z, Hu N, Zhang D, Quan G, Wu Y, Feng J, Shen B, Zhao J, Zhang Y, Yang K, Luo L. Screening and Identification of a Novel Anti-Siglec-15 Human Antibody 3F1 and Relevant Antitumor Activity Mol Pharmacol. 2022 Sep;102(3):161-171._x000D_ 6: Lenza MP, Egia-Mendikute L, Anto√±ana-Vildosola A, Soares CO, Coelho H, Corzana F, Bosch A, Manisha P, Quintana JI, Oyenarte I, Unione L, Moure MJ, Azkargorta M, Atxabal U, Sobczak K, Elortza F, Sutherland JD, Barrio R, Marcelo F, Jim√©nez-Barbero J, Palazon A, Ere√±o-Orbea J. Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b Nat Commun. 2023 Jun 13;14(1):3496._x000D_ 7: Korn MA, Schmitt H, Angerm√ºller S, Chambers D, Seeling M, Lux UT, Brey S, Royzman D, Br√ºckner C, Popp V, Percivalle E, B√§uerle T, Zinser E, Winkler TH, Steinkasserer A, Nimmerjahn F, Nitschke L. Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis J Immunol. 2020 Nov 15;205(10):2595-2605._x000D_ 8: Sato D, Takahata M, Ota M, Fukuda C, Tsuda E, Shimizu T, Okada A, Hiruma Y, Hamano H, Hiratsuka S, Fujita R, Amizuka N, Hasegawa T, Iwasaki N. Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth Bone. 2018 Nov;116:172-180._x000D_ 9: Sato D, Takahata M, Ota M, Fukuda C, Hasegawa T, Yamamoto T, Amizuka N, Tsuda E, Okada A, Hiruma Y, Fujita R, Iwasaki N. Siglec-15-targeting therapy protects against glucocorticoid-induced osteoporosis of growing skeleton in juvenile rats Bone. 2020 Jun;135:115331._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34988324">10: He F, Wang N, Li J, He L, Yang Z, Lu J, Xiong G, Yu C, Wang S. High affinity monoclonal antibody targeting Siglec-15 for cancer immunotherapy J Clin Transl Res. 2021 Nov 16;7(6):739-749. eCollection 2021 Dec 28.</a>_x000D_ _x000D_ <strong>Products Related to Rabbit anti-SIGLEC-15 Monoclonal Antibody can be found at</strong> <a href="https://moleculardepot.com/product-category/Antibodies/"> Antibodies</a>