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1-Monopalmitin (Standard)

1-Monopalmitin (Glyceryl palmitate) (Standard) is the analytical standard of 1-Monopalmitin. This product is intended for research and analytical applications. 1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC50=50-58 μg/mL), with low toxicity to normal cells[1][2].

Product Specifications

CAS Number

542-44-9

Product Name Alternative

Glyceryl palmitate (Standard)

UNSPSC

12352211

Target

Akt; Apoptosis; Caspase; IAP; P-glycoprotein; PI3K; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-monopalmitin-standard.html

Smiles

OC(CO)COC(CCCCCCCCCCCCCCC)=O

Molecular Formula

C19H38O4

Molecular Weight

330.51

References & Citations

[1]Tomoko Konishi, et al. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound. Biofactors. 2004;22 (1-4) :71-4.|[2]Niu L, et al. 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/A kt pathway in vitro. Environmental Toxicology, 2023, 38 (11) : 2621-2631.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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