(S) -Sunvozertinib
(S) -Sunvozertinib ((S) -DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively) . (S) -Sunvozertinib also inhibits BTK[1].
Product Specifications
CAS Number
[2370013-49-1]
Product Name Alternative
(S) -DZD9008
UNSPSC
12352005
Target
Btk; EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-sunvozertinib.html
Purity
99.05
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C=CC(NC1=C(N2C[C@H](CC2)N(C)C)C=C(C(NC3=NC=CC(NC4=C(C=C(C(Cl)=C4)F)C(C)(O)C)=N3)=C1)OC)=O
Molecular Formula
C29H35ClFN7O3
Molecular Weight
584.08
References & Citations
[1]Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2
Available Sizes
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