THRX-144644
THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition[1].
Product Specifications
CAS Number
[2442519-59-5]
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thrx-144644.html
Purity
99.90
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC(F)=C(C2=NNC=C2C3=NC4=C(C=C3)N=CC(NCCN5CCN(C(C)C)CC5)=C4)C=C1Cl
Molecular Formula
C26H28ClF2N7
Molecular Weight
512.00
References & Citations
[1]Maher JM, et, al. Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition. Toxicol Appl Pharmacol. 2022 Mar 1;438:115905.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK5
Available Sizes
Curated Selection
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