Varlilumab (anti-CD27)
Varlilumab (CDX-1127) (anti-CD27) is an agonist anti-CD27 monoclonal antibody. Varlilumab (anti-CD27) can promote T cell expansion and activate the immune response. Varlilumab (anti-CD27) has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors[1][2].
Product Specifications
CAS Number
1393344-72-3
Product Name Alternative
CDX-1127 (anti-CD27)
UNSPSC
12352203
Target
TNF Receptor; Transmembrane Glycoprotein
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/varlilumab-anti-cd27.html
Purity
99.68
Solubility
10 mM in DMSO
Smiles
[Varlilumab(anti-CD27)]
Molecular Weight
(145.58 kDa)
References & Citations
[1]Stephen M Ansell, et al. Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies. Blood Adv. 2020 May 12;4 (9) :1917-1926.|[2]Wasiuk A, et al. Conditioning treatment with CD27 Ab enhances expansion and antitumor activity of adoptively transferred T cells in mice. Cancer Immunol Immunother. 2022 Jan;71 (1) :97-109.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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