Urolithin B

Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality[1][2][3][4].

Product Specifications

CAS Number

[1139-83-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; AMPK; Endogenous Metabolite; ERK; JNK; NF-κB

Type

Natural Products

Related Pathways

Epigenetics; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/urolithin-b.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=CC=C2C3=CC=C(O)C=C3O1

Molecular Formula

C13H8O3

Molecular Weight

212.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57.|[2]Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8 (4) :583-597.|[3]Lv MY, et al. Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β-catenin signaling. J Cell Biochem. 2019 Oct;120 (10) :17273-17282.|[4]Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8 (4) :583-597.