Human CXCR3 Full Length Protein (VLP)
Human CXCR3 Full Length Protein-VLP (CX3-H52P4) is expressed from human 293 cells (HEK293) . It contains AA Val 2 - Leu 368 (Accession # P49682-1) .
Product Specifications
Background
Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis) . However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis) . Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
Specifications
This protein .
Accession Number
P49682-1
Expression Region
Val 2 - Leu 368
Host
HEK293
Target
CXCR3
Conjugation
Unconjugated
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 12 months under sterile conditions.
Endotoxin
1.0 EU per μg
Bioactivity
Immobilized Human CXCR3 Full Length Protein-VLP (Cat. No. CX3-H52P4) at 5 μg/mL (100 μL/well) can bind Anti-CXCR3 Antibody, Human IgG1 with a linear range of 0.8-6 ng/mL (QC tested).
Format
Liquid
Buffer
PBS, Arginine, pH7.4
Additives
Trehalose
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CX3-H52P4.pdf
Species
Human
Curated Selection
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