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Cytisinicline (Standard)

Cytisinicline (Standard) is the analytical standard of Cytisinicline. This product is intended for research and analytical applications. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3].

Product Specifications

CAS Number

485-35-8

Product Name Alternative

Cytisine (Standard) ; Sophorine (Standard) ; Baptitoxine (Standard)

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

NAChR; Reference Standards

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/cytisinicline-standard.html

Purity

99.90

Smiles

O=C1N(C[C@@]2([H])C[C@]3([H])CNC2)C3=CC=C1

Molecular Formula

C11H14N2O

Molecular Weight

190.24

Precautions

H301, H315, H319, H335

References & Citations

[1]Pabreza LA, et al. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991 Jan;39 (1) :9-12.|[2]Grebenstein PE, et al. The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2013 Sep;110:192-200.|[3]Walker N, et al. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014 Dec 18;371 (25) :2353-62.|[4]Yu L, et al. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018 Mar;39 (3) :1475-1484.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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