Melinamide
Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.
Product Specifications
CAS Number
14417-88-0
Product Name Alternative
AC 223; DL-N- (α-Methylbenzyl) linoleamide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Melinamide.html
Purity
99.9
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCC/C=C\C/C=C\CCCCCCCC(NC(C1=CC=CC=C1)C)=O
Molecular Formula
C26H41NO
Molecular Weight
383.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Kusunoki J, et al. Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells Nihon Yakurigaku Zasshi. 1997 Dec;110 (6) :357-65.|[2]Natori K, et al. Mechanism of the inhibition of cholesterol absorption by DL-melinamide: inhibition of cholesterol esterification. Jpn J Pharmacol. 1986 Dec;42 (4) :517-23.|[3]Matsubara K, et al. Cholesterol-lowering effect of N- (alpha-methylbenzyl) linoleamide (melinamide) in cholesterol-fed diabetic rats. Atherosclerosis. 1988 Aug;72 (2-3) :199-204.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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