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Phe-Lys (Fmoc) -PAB

Phe-Lys (Fmoc) -PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

2149584-03-0

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phe-lys-fmoc-pab.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCC(C=C1)=CC=C1NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCCNC(OCC3C4=CC=CC=C4C5=CC=CC=C35)=O)=O

Molecular Formula

C37H40N4O5

Molecular Weight

620.74

Precautions

H302, H315, H319, H335

References & Citations

[1]Abu Ajaj K, et al. Development of protein-binding bifunctional linkers for a new generation of dual-actingprodrugs. Bioconjug Chem. 2009 Feb;20 (2) :390-6.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker; Protease Cleavable Linker

Available Sizes

Frequently Asked Questions

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