EpskA21
Product Specifications
UNSPSC Description
EpskA21 is an inhibitor for PI3K/AKT signaling pathway, and inhibits the proliferation of cancer cells MCF-7, A549, MIA-PaCa-2, Panc-1 and HepG2, with IC50 of 1.3-7.24 μM. EpskA21 inhibits the cell migration, arrests the cell cycle at G2/M (MCF-7) and S (MIA-PaCa-2) phase, and induces apoptosis in MCF-7 and MIA-PaCa-2. EpskA21 causes the mitochondrial dysfunction[1].
Target Antigen
Akt; Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/epska21.html
Smiles
C=C1[C@H]2[C@@H](OC(/C=C/C3=CC=NC=C3)=O)[C@]4(C1=O)C([C@H]5[C@]6([H])C(C)(C)C(C=C[C@@]6(CO5)[C@]4([H])CC2)=O)=O
Molecular Weight
473.52
References & Citations
[1]Li H, et al., Design and synthesis of 6,20-epoxy A-ring modified oridonin derivatives with antitumor activity through extrinsic and mitochondrial pathways. Bioorg Chem. 2024 Jul 11;151:107632.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161858/EpskA21-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161858/
Clinical Information
No Development Reported
Curated Selection
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