EpskA21

EpskA21 is an inhibitor for PI3K/AKT signaling pathway, and inhibits the proliferation of cancer cells MCF-7, A549, MIA-PaCa-2, Panc-1 and HepG2, with IC50 of 1.3-7.24 μM. EpskA21 inhibits the cell migration, arrests the cell cycle at G2/M (MCF-7) and S (MIA-PaCa-2) phase, and induces apoptosis in MCF-7 and MIA-PaCa-2. EpskA21 causes the mitochondrial dysfunction[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/epska21.html

Smiles

C=C1[C@H]2[C@@H](OC(/C=C/C3=CC=NC=C3)=O)[C@]4(C1=O)C([C@H]5[C@]6([H])C(C)(C)C(C=C[C@@]6(CO5)[C@]4([H])CC2)=O)=O

Molecular Formula

C28H27NO6

Molecular Weight

473.52

References & Citations

[1]Li H, et al., Design and synthesis of 6,20-epoxy A-ring modified oridonin derivatives with antitumor activity through extrinsic and mitochondrial pathways. Bioorg Chem. 2024 Jul 11;151:107632.