Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Elacridar (hydrochloride)

Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer[1][2].

Product Specifications

CAS Number

143851-98-3

Product Name Alternative

GF120918A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

BCRP; P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/elacridar-hydrochloride.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 7 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC=CC(C(NC(C=C3)=CC=C3CCN4CC(C=C(C(OC)=C5)OC)=C5CC4)=O)=C2NC6=C1C=CC=C6OC.[H]Cl

Molecular Formula

C34H34ClN3O5

Molecular Weight

600.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Sane R, et al. Brain distribution and bioavailability of elacridar after different routes of administration in the mouse. Drug Metab Dispos. 2012 Aug;40 (8) :1612-9.|[2]Sato H, et al. Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells. Eur J Pharmacol. 2015 Jan 5;746:258-66.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Crit Rev Anal Chem. 2022;52 (7) :1557-1571.|Food Chem Toxicol. 2021 Sep:155:112381.|J Mater Chem B. 2018 Dec 7;6 (45) :7521-7529.|Mol Psychiatry. 2023 Sep;28 (9) :3930-3942.|Xenobiotica. 2024 Aug 10:1-15.|Antiviral Res. 2021 Sep:193:105124.|Arch Toxicol. 2025 Jun 7.|Biomed Pharmacother. 2020 Sep;129:110506.|Biomed Res Int. 2020 Nov 29;2020:8878158.|Cancer Lett. 2024 Nov 25:217355.|Cell Death Dis. 2021 Jul 27;12 (8) :742.|Cell Death Dis. 2019 May 24;10 (6) :400. |Cell Metab. 2024 Mar 5;36 (3) :498-510.e11.|Cell Rep. 2020 Jun 23;31 (12) :107782.|Chem Res Toxicol. 2025 Aug 12.|Clin Cancer Res. 2018 Jan 15;24 (2) :383-394.|EJNMMI Res. 2015 Mar 17:5:11.|Eur J Med Chem. 2023 Nov 15:260:115721.|Eur J Pharm Sci. 2025 Sep 1:212:107194.|Hong Kong Polytechnic University. 2022 Oct.|Int J Biol Macromol. 2024 Feb 21;264 (Pt 1) :130377.|Int J Mol Sci. 2019 Mar 5;20 (5) . pii: E1125. |J Agric Food Chem. 2019 Feb 27;67 (8) :2350-2360.|J Agric Food Chem. 2022 Feb 16;70 (6) :1923-1933.|J Biol Chem. 2022 Sep;298 (9) :102353.|J Drug Target. 2016;24 (5) :441-9.|Molecules. 2019 Apr 27;24 (9) :1661.|Preprints. 2024 Jun 19.|Sci Adv. 2023 Oct 20;9 (42) :eabp9530.|Sci Rep. 2021 Jul 22;11 (1) :14948.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Chimaerin 2 (CHN2) (NM_004067) Human Recombinant Protein
TP311342M 100 µg

Chimaerin 2 (CHN2) (NM_004067) Human Recombinant Protein

Sign In for Pricing
View Details
MAPKAP Kinase 3 (MAPKAPK3) Rabbit Polyclonal Antibody
TA370884 100 µL

MAPKAP Kinase 3 (MAPKAPK3) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
GMP Human TGF-Beta 1 / TGFB1 Protein
GMP-TG1H25-500ug 500 µg

GMP Human TGF-Beta 1 / TGFB1 Protein

Sign In for Pricing
View Details
Pentathiodiphosphorus(V) Acid P,P′-Bis(pyridinium betaine) (Technical Grade)
TRC-P698181-2.5G 2.5 g

Pentathiodiphosphorus(V) Acid P,P′-Bis(pyridinium betaine) (Technical Grade)

Sign In for Pricing
View Details
CD69 Mouse Monoclonal Antibody [A8C4]
HA601013 100 µL

CD69 Mouse Monoclonal Antibody [A8C4]

Sign In for Pricing
View Details
Human TA3 (TAAR9) activation kit by CRISPRa
GA115238 1 Kit

Human TA3 (TAAR9) activation kit by CRISPRa

Sign In for Pricing
View Details