DAMGO
DAMGO is a μ-opioid receptor (μ-OPR) selective agonist with a Kd of 3.46 nM for native μ-OPR[1].
Product Specifications
CAS Number
78123-71-4
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DAMGO.html
Purity
99.87
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N(C)[C@H](C(NCCO)=O)CC2=CC=CC=C2)=O)=O)=O)C=C1
Molecular Formula
C26H35N5O6
Molecular Weight
513.59
References & Citations
[1]FEBS Lett. 1995 Jan 2;357 (1) :93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.|[2]Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12 (6) :492-500.|[3]Gold MS, et al. DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro. Neurosci Lett. 1996 Jul 12;212 (2) :83-6.|[4]Desmeules JA, et al. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain. 1993 Jun;53 (3) :277-285.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
μ Opioid Receptor/MOR
Citation 01
Alzheimers Res Ther. 2025 Feb 1;17 (1) :35.|Aquaculture. 2025 Apr 15.|bioRxiv. 2022 Jul 11.|bioRxiv. 2024 Jul 26:2024.07.26.605282.|Cell Rep Methods. 2025 May 19;5 (5) :101051.|Nature. 2025 Dec;648 (8094) :755-763.|Seoul National University. 2024 Feb.|Cell. 2022 Nov 10;185 (23) :4361-4375.e19.|Cell. 2023 Jan 19;186 (2) :413-427.e17.
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