DAMGO

DAMGO is a μ-opioid receptor (μ-OPR) selective agonist with a Kd of 3.46 nM for native μ-OPR[1].

Product Specifications

CAS Number

[78123-71-4]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/DAMGO.html

Purity

99.87

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N(C)[C@H](C(NCCO)=O)CC2=CC=CC=C2)=O)=O)=O)C=C1

Molecular Formula

C26H35N5O6

Molecular Weight

513.59

References & Citations

[1]FEBS Lett. 1995 Jan 2;357 (1) :93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.|[2]Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12 (6) :492-500.|[3]Gold MS, et al. DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro. Neurosci Lett. 1996 Jul 12;212 (2) :83-6.|[4]Desmeules JA, et al. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain. 1993 Jun;53 (3) :277-285.