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KLF10-IN-1

KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC50 value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25 T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology[1].

Product Specifications

CAS Number

1197834-98-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/klf10-in-1.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(OCC(C1=CC=C(OC)C=C1)=O)C2=CC(C)=CC=C2O

Molecular Formula

C17H16O5

Molecular Weight

300.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Khedkar SA, et al. Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10) : implications for modulation of T regulatory cell differentiation. J Med Chem. 2015;58 (3) :1466-1478.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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