NCC-149
NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1].
Product Specifications
CAS Number
1316652-41-1
Product Name Alternative
L-APB (monohydrate),D-APB; D-2-Amino-4-phosphonobutyric acid,L-APB,l-Bicuculline (methobromide),2-APH; 2-Amino-7-phosphonoheptanoic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ncc-149.html
Purity
99.29
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NO)C1=CC=CC(C2=CN(CSC3=CC=CC=C3)N=N2)=C1
Molecular Formula
C16H14N4O2S
Molecular Weight
326.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Katayama S, et al. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498 (1) :45-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC8
Available Sizes
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