SW033291
SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration[1].
Product Specifications
CAS Number
459147-39-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
15-PGDH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/SW033291.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 70°C) |Ethanol : 25 mg/mL (ultrasonic)
Smiles
NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21
Molecular Formula
C21H20N2OS3
Molecular Weight
412.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang Y, et al. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun 12;348 (6240) :aaa2340.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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