What is the catalog number for Fedratinib?

The catalog number for Fedratinib is HY-10409.

What sizes are available for Fedratinib?

Fedratinib is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 100 mg, 200 mg, 500 mg, 1 g, 2 g, 5 g.

How many pack sizes does Fedratinib come in?

Fedratinib is available in 9 different pack sizes.

Is Fedratinib in stock?

Fedratinib is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Fedratinib?

Fedratinib is manufactured by QuantiMol.

What is the estimated delivery time for Fedratinib?

Estimated delivery time for Fedratinib is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Fedratinib?

The safety data sheet for Fedratinib is available here: http://file.medchemexpress.com/batch_PDF/HY-10409/Fedratinib-SDS-MedChemExpress.pdf.

Fedratinib

Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research[1][2].

Product Specifications

CAS Number

936091-26-8

Product Name Alternative

TG-101348; SAR 302503

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; JAK

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TG-101348.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)OCCN4CCCC4)=NC=C2C)=C1)(NC(C)(C)C)=O

Molecular Formula

C27H36N6O3S

Molecular Weight

524.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Wernig G, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13 (4) :311-20.|[2]Geron I, et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 Apr;13 (4) :321-30.