SJF-1521

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research. (Pink: EGFR ligand (HY-177379) ; Black: Linker (HY-128804) ; Blue: VHL Ligand (HY-125845) ) [1].

Product Specifications

CAS Number

[2230821-40-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR; PROTACs

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sjf-1521.html

Purity

99.65

Solubility

DMSO : ≥ 200 mg/mL

Smiles

O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOC(C=C4)=CC=C4C5=CC(C(NC6=CC(Cl)=C(C=C6)OCC7=CC(F)=CC=C7)=NC=N8)=C8C=C5)=O

Molecular Formula

C57H61ClFN7O9S

Molecular Weight

1074.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25 (1) :67-77.e3.