GDC-0334
GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma[1][2].
Product Specifications
CAS Number
1984824-54-5
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gdc-0334.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(S(=O)(C2=CC=C(F)C=C2)=O)[C@@H](C)[C@H](F)C1)NCC3=CC(C4=CN=C(C(F)(F)F)N=C4)=NC=C3C(F)(F)F
Molecular Formula
C24H19F8N5O3S
Molecular Weight
609.49
References & Citations
[1]Estrada A, et al. 1- (het) arylsulfonyl- (pyrrolidine or piperidine) -2-carboxamide derivatives and their use as trpa1 antagonists. WO2016128529 A1.|[2]Balestrini A, et.al A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment. J Exp Med. 2021 Apr 5;218 (4) :e20201637.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
TRPA1
Available Sizes
Frequently Asked Questions
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