Tankyrase 2 Recombinant Rabbit Monoclonal Antibody [PSH0-53]
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
TNKS2, PARP5B, TANK2, TNKL
Swiss Prot
Q9H2K2 Human,
Cellular Locus
Cytoplasm, Golgi apparatus membrane, Nucleus, Chromosome, telomere.
Host
Rabbit
Species Reactivity
Human,Rat
Immunogen
Recombinant protein within human Tankyrase 2 aa 451-700/1,166.
Isotype
IgG
Clone
PSH0-53
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell
Positive Control
PC-12 treated with 1μM XAV939 for 24 hours whole cell lysate, PC-12 treated with 1μM XAV939 for 48 hours whole cell lysate, A431.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:250
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 127 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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