PfDHODH-IN-2
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 μM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].
Product Specifications
CAS Number
[425629-94-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfdhodh-in-2.html
Purity
99.83
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC2=CC=C(Cl)C=C2)SCC1=O)OCC
Molecular Formula
C13H12ClNO3S
Molecular Weight
297.76
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
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