PfDHODH-IN-2

PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 μM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].

Product Specifications

CAS Number

[425629-94-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dihydroorotate Dehydrogenase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pfdhodh-in-2.html

Purity

99.83

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C1=C(NC2=CC=C(Cl)C=C2)SCC1=O)OCC

Molecular Formula

C13H12ClNO3S

Molecular Weight

297.76

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56 (20) :7911-24.