PfDHODH-IN-2
Product Specifications
UNSPSC Description
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 μM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].
Target Antigen
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfdhodh-in-2.html
Purity
99.83
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC2=CC=C(Cl)C=C2)SCC1=O)OCC
Molecular Weight
297.76
References & Citations
[1]Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W078844/PfDHODH-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W078844/PfDHODH-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
425629-94-3
Available Sizes
Curated Selection
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