PRN1371
PRN1371 is a highly selective and potent FGFR1-4 and CSF1R inhibitor with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, FGFR2, FGFR3, FGFR4 and CSF1R, respectively[1].
Product Specifications
CAS Number
[1802929-43-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Fms; FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PRN1371.html
Purity
99.78
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C(C2=C(Cl)C(OC)=CC(OC)=C2Cl)=CC3=CN=C(NC)N=C3N1CCCN4CCN(C(C=C)=O)CC4
Molecular Formula
C26H30Cl2N6O4
Molecular Weight
561.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Brameld KA, et al. Discovery of the Irreversible Covalent FGFR Inhibitor 8- (3- (4-Acryloylpiperazin-1-yl) propyl) -6- (2,6-dichloro-3,5-dimethoxyphenyl) -2- (methylamino) pyrido[2,3-d]pyrimidin-7 (8H) -one (PRN1371) for the Treatment of Solid Tumors. J Med Chem. 2017 Aug 10;60 (15) :6516-6527.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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