20-5,14-HEDGE

20-5,14-HEDGE is a 20-HETE analog. 20-5,14-HEDGE induces cell death in organotypic hippocampal slice cultures (OHSCs) . 20-5,14-HEDGE enhances ROS production and reduces hypoxia-reoxygenation (HR) -induced apoptosis in ex vivo rat lung slices. 20-5,14-HEDGE protects against lung ischemic reperfusion injury in rats. 20-5,14-HEDGE can be used for the study of pulmonary vascular signaling and lung injury-related research[1][2][3].

Product Specifications

CAS Number

[1092380-14-7]

UNSPSC

12352211

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/20-5-14-hedge.html

Purity

99.28

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(CNC(CCC/C=C\CCCCCCC/C=C\CCCCCO)=O)=O

Molecular Formula

C22H39NO4

Molecular Weight

381.55

References & Citations

[1]Ali I, et al. Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ann Thorac Surg. 2012 Jan;93 (1) :282-8.|[2]Han R, et al. 20-HETE Participates in Intracerebral Hemorrhage-Induced Acute Injury by Promoting Cell Ferroptosis. Front Neurol. 2021 Nov 12;12:763419. |[3]Jacobs ER, et al. Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. Exp Cell Res. 2012 Oct 1;318 (16) :2143-52.