Fidarestat

Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

Product Specifications

CAS Number

[136087-85-9]

Product Name Alternative

SNK 860

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Fidarestat.html

Purity

99.63

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1NC(N[C@@]12C3=C(C=CC(F)=C3)O[C@H](C(N)=O)C2)=O

Molecular Formula

C12H10FN3O4

Molecular Weight

279.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Ruiz FX, et al. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP (+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202 (1-3) :178-85.|[2]Hotta N, et al. Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Exp Physiol. 1995 Nov;80 (6) :981-9.