Simazine

Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice[1][2][3].

Product Specifications

CAS Number

[122-34-9]

UNSPSC

12352005

Hazard Statement

H302, H351, H400, H410

Target

Apoptosis; Bcl-2 Family; Caspase; Herbicide; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/simazine.html

Purity

99.72

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCNC1=NC(Cl)=NC(NCC)=N1

Molecular Formula

C7H12ClN5

Molecular Weight

201.66

Precautions

H302, H351, H400, H410

References & Citations

[1]Morten T Strandberg, et al. Field Effects of Simazine at Lower Trophic Levels--A Review. ci Total Environ. 2002 Sep 16;296 (1-3) :117-37.|[2]Ren R, et al. Oral exposure to the herbicide simazine induces mouse spleen immunotoxicity and immune cell apoptosis. Toxicol Pathol. 2013 Jan;41 (1) :63-72.|[3]Shang JZ, et al. Simazine perturbs the maturational competency of mouse oocyte through inducing oxidative stress and DNA damage. Ecotoxicol Environ Saf. 2022 Jan 15;230:113105.