HCAIX/XII-IN-13
HCAIX/XII-IN-13 is an inhibitor of human carbonic anhydrases (hCA). hCAIX/XII-IN-13 shows good inhibitory activity against the tumor-related CA subtypes IX and XII, with Ki values of 0.08 µM and 0.06 µM, respectively. Under hypoxic conditions, hCAIX/XII-IN-13 can restore the cytotoxicity of Doxorubicin on MCF-7 cells, increasing G2/M phase cell cycle arrest and apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-xii-in-13.html
Smiles
O=C(C(C1=NC(N=C(N(C2=CC=C(S(N)(=O)=O)C=C2)N=C3C(C)=O)N3C4=O)=C4C=C1)=C5)OC6=C5C=CC=C6
Molecular Formula
C25H16N6O6S
Molecular Weight
528.50
References & Citations
[1]Abdelaal HI, et al. Mitigating the resistance of MCF-7 cancer cells to Doxorubicin under hypoxic conditions with novel coumarin based carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2024 Nov;152:107759.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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