HCAIX/XII-IN-13

HCAIX/XII-IN-13 is an inhibitor of human carbonic anhydrases (hCA) . hCAIX/XII-IN-13 shows good inhibitory activity against the tumor-related CA subtypes IX and XII, with Ki values of 0.08 µM and 0.06 µM, respectively. Under hypoxic conditions, hCAIX/XII-IN-13 can restore the cytotoxicity of Doxorubicin (HY-15142A) on MCF-7 cells, increasing G2/M phase cell cycle arrest and apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcaix-xii-in-13.html

Smiles

O=C(C(C1=NC(N=C(N(C2=CC=C(S(N)(=O)=O)C=C2)N=C3C(C)=O)N3C4=O)=C4C=C1)=C5)OC6=C5C=CC=C6

Molecular Formula

C25H16N6O6S

Molecular Weight

528.50

References & Citations

[1]Abdelaal HI, et al. Mitigating the resistance of MCF-7 cancer cells to Doxorubicin under hypoxic conditions with novel coumarin based carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2024 Nov;152:107759.