DHICA
DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of true black pigment, and it’s also a moderately potent GPR35 agonist. DHICA shows an ability to stimulate β-arrestin translocation signaling with an EC50 value of 23.2 μM in the U2OS cell line. DHICA plays a significant role in promoting and protecting against DNA damage[1][2].
Product Specifications
CAS Number
4790-08-3
Product Name Alternative
5,6-Dihydroxyindole-2-carboxylic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Arrestin; Endogenous Metabolite; GPR35
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dhica.html
Purity
97.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C1=CC2=C(C=C(C(O)=C2)O)N1)=O
Molecular Formula
C9H7NO4
Molecular Weight
193.16
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
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