DHICA

DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of true black pigment, and it’s also a moderately potent GPR35 agonist. DHICA shows an ability to stimulate β-arrestin translocation signaling with an EC50 value of 23.2 μM in the U2OS cell line. DHICA plays a significant role in promoting and protecting against DNA damage[1][2].

Product Specifications

CAS Number

[4790-08-3]

Product Name Alternative

5,6-Dihydroxyindole-2-carboxylic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Arrestin; Endogenous Metabolite; GPR35

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dhica.html

Purity

97.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C1=CC2=C(C=C(C(O)=C2)O)N1)=O

Molecular Formula

C9H7NO4

Molecular Weight

193.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Huayun Deng, et al. Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues. ACS Med Chem Lett. 2012 Jun 6;3 (7) :550-4.|[2]Maria Carolina Pellosi, et al. Effects of the melanin precursor 5,6-dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species. Arch Biochem Biophys. 2014 Sep 1:557:55-64.