Vimentin-IN-1

Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and pharmacokinetic profiles than FiVe1[1].

Product Specifications

CAS Number

[2319587-80-7]

UNSPSC

12352005

Target

Mitosis; Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vimentin-in-1.html

Purity

99.74

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

COC1=CC(Cl)=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=C1

Molecular Formula

C19H18Cl2N4O

Molecular Weight

389.28

References & Citations

[1]Martínez-Peña F, et al. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15;242:114638.