Vimentin-IN-1
Product Specifications
UNSPSC Description
Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III?intermediate filament protein?vimentin?(VIM), to induce hyperphosphorylation?of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and?pharmacokinetic?profiles than FiVe1[1].
Target Antigen
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vimentin-in-1.html
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
COC1=CC(Cl)=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=C1
Molecular Weight
389.28
References & Citations
[1]Martínez-Peña F, et al. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15;242:114638.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151424/Vimentin-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151424/Vimentin-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2319587-80-7
Available Sizes
Curated Selection
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