FGFR4-IN-19

FGFR4-IN-19 (compound 8B) is a potent covalent fibroblast growth factor receptor 4 (FGFR4) inhibitor (IC50=1.2 nM) . FGFR4-IN-19 achieves high efficiency and isotype selectivity by covalently targeting a rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 can be used for hepatocellular carcinoma (HCC) research[1].

Product Specifications

UNSPSC

12352005

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr4-in-19.html

Solubility

10 mM in DMSO

Smiles

ClC(N=C1NC2=NC=C3C(C=CC(C4=C(C(OC)=CC(OC)=C4Cl)Cl)=C3)=N2)=CC=C1[N+]([O-])=O

Molecular Formula

C21H14Cl3N5O4

Molecular Weight

506.73

References & Citations

[1]Schwarz M, et al. Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles[J]. Journal of Medicinal Chemistry, 2024.