Cyclorasin 9A5 (TFA)
Product Specifications
UNSPSC Description
Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM[1].
Target Antigen
Raf; Ras
Type
Peptides
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclorasin-9a5-tfa.html
Purity
99.57
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(N[C@@](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)([H])[C@H](O)C)[C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC1=O)CC2=CC(C=CC=C3)=C3C=C2)=O)CCCNC(N)=N)=O)CC(C=C4)=CC=C4F)=O)CCCC)=O)CCC(N)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O.[x]
Molecular Weight
1586.82 (free base)
References & Citations
[1]Koh Takeuchi, et al. Conformational Plasticity of Cyclic Ras-Inhibitor Peptides Defines Cell Permeabilization Activity. Angew Chem Int Ed Engl. 2021 Mar 15;60(12):6567-6572.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10051A/Cyclorasin-9A5-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10051A/
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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