Cyclorasin 9A5 (TFA)

Cyclorasin 9A5 TFA is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM[1].

Product Specifications

UNSPSC

12352209

Target

Raf; Ras

Type

Peptides

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclorasin-9a5-tfa.html

Purity

99.57

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(N[C@@](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)([H])[C@H](O)C)[C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC1=O)CC2=CC(C=CC=C3)=C3C=C2)=O)CCCNC(N)=N)=O)CC(C=C4)=CC=C4F)=O)CCCC)=O)CCC(N)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O.[x]

Molecular Formula

C75H108FN25O13.xC2HF3O2

Molecular Weight

1586.82 (free base)

References & Citations

[1]Koh Takeuchi, et al. Conformational Plasticity of Cyclic Ras-Inhibitor Peptides Defines Cell Permeabilization Activity. Angew Chem Int Ed Engl. 2021 Mar 15;60 (12) :6567-6572.